Medicine

Progressing ASO therapies coming from development to application

.Competing passions.R.S., M.S., H.G. as well as A.A.R. are actually planners of the 1M1M campaign. H.G. and also A.A.R. are actually board of directors members as well as R.S., M.S. as well as A.A.R. are actually participants of the medical advising board of N1C. A.A.R. discloses work by LUMC, which possesses patents on exon-skipping technology, a few of which has been accredited to BioMarin as well as ultimately sublicensed to Sarepta. As co-inventor of several of these licenses, A.A.R. was qualified to a portion of royalties. A.A.R. additionally discloses functioning as impromptu consultant for PTC Therapies, Sarepta Rehabs, Regenxbio, Dyne Rehabs, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and Astra Zeneca. Over the last 5 years, A.A.R. additionally did ad hoc speaking with for Alpha Anomeric. A.A.R. also reports membership of the clinical boards of advisers of Eisai, Hybridize Therapies, Muteness Therapeutics, Sarepta Therapeutics, Sapreme and also Mitorx. Over the last 5 years, A.A.R. was actually additionally a medical advisory board participant for ProQR. Remuneration for A.A.R. u00e2 s consulting and also suggesting activities is paid for to LUMC. In the past 5 years, LUMC also received speaker honoraria from PTC Rehabs, Alnylam Netherlands, Italfarmaco and Pfizer and financing for agreement investigation coming from Sapreme, Eisai, Galapagos, Synaffix and Alpha Anomeric. Project funding is obtained coming from Sarepta Therapies and also Entrada via unlimited grants. H.G. possesses nothing to reveal in connection with the subjects dealt with within this composition. Over the last 5 years, he has additionally obtained working as a consultant honoraria coming from UCB. M.S. received consultancy honoraria from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and Solaxa over the last 5 years, all unassociated to the present composition. R.S. has absolutely nothing to disclose relative to the topics dealt with within this document. She has actually acquired speaker and/or working as a consultant gratuity or even funding contributions coming from Abbvie, Bial, STADA and also Everpharma over the last 5 years.

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